Adachi-Usami E, Mizota A, Ikeda H, Hanawa T, Kimura T
Department of Ophthalmology, Chiba University School of Medicine, Japan.
Invest Ophthalmol Vis Sci. 1992 Oct;33(11):3109-13.
Twenty C57 black mice received an injection of 40 mg/kg of sodium iodate through the caudal vein. The electroretinograms (ERGs) were recorded before and after injection. Flash stimuli with the maximum illuminance, 30,000 lux, were given at increasing levels of illuminance in 0.6 log U steps for 13 levels of intensity. The a- and b-wave amplitudes increased linearly with increased stimulus intensity for approximately 5.0 log U before being saturated. Twenty four hours after injection, the intensity-amplitude curve shifted toward the higher intensity region. It was calculated that the sensitivity loss of the b-wave after injection was 2.0 log U, although the maximum amplitude was larger and the peak latency was delayed. The same results were seen less obviously in the ERGs 48 hr after injection. After 96 hr, both waves were greatly attenuated and even abolished. At the time the increased ERGs were recorded, the histopathologic findings exhibited severe damage of the retina in the pigment epithelium and in the outer layer.
20只C57黑鼠通过尾静脉注射40mg/kg碘酸钠。在注射前后记录视网膜电图（ERG）。以最大照度30000勒克斯进行闪光刺激，以0.6对数单位（log U）的步长增加照度水平，共13个强度级别。在达到饱和之前，a波和b波振幅随刺激强度增加呈线性增加，约为5.0 log U。注射后24小时，强度-振幅曲线向更高强度区域移动。计算得出注射后b波的敏感度损失为2.0 log U，尽管最大振幅更大且峰值潜伏期延迟。注射后48小时在ERG中也观察到了相同结果，但不太明显。96小时后，两个波都大幅衰减甚至消失。在记录到ERG增强时，组织病理学检查结果显示色素上皮和外层视网膜有严重损伤。
