Treves T A, Streiffler M, Korczyn A D
Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University Ramat Aviv, Israel.
Headache. 1992 Jun;32(6):280-2. doi: 10.1111/j.1526-4610.1992.hed3206280.x.
A double-blind parallel study compared the efficacy and safety of naproxen sodium (NPX) and ergotamine tartrate (ERG) as abortive therapy for acute headache in 79 patients with classical or common migraine. The design study was of the double-blind design. Forty-two patients completed the study. Discontinuation of treatment was generally due to lack of efficacy or adverse reactions. NPX was significantly better than ERG in the overall efficacy of treatment rated by the patients (p less than 004). NPX was comparable to ERG in reducing the severity and duration of the headache and its associated symptoms. In classical migraine, NPX was better than ERG in alleviating the severity of headache. Patients in the NPX group tended to use less rescue medication. There was no significant difference in the frequency of side-effects reported by the patients under NPX or ERG. This study demonstrates that NPX is as safe as ERG, and somewhat more effective in acute migraine attacks (although the difference is not statistically significant) and that migrainous patients tend to prefer NPX to ERG in treating their acute migraine headaches.
一项双盲平行研究比较了萘普生钠（NPX）和酒石酸麦角胺（ERG）作为79例典型或普通偏头痛患者急性头痛终止治疗的疗效和安全性。该设计研究采用双盲设计。42例患者完成了研究。治疗中断通常是由于缺乏疗效或出现不良反应。患者对治疗总体疗效的评价中，NPX显著优于ERG（p<0.04）。在减轻头痛及其相关症状的严重程度和持续时间方面，NPX与ERG相当。在典型偏头痛中，NPX在减轻头痛严重程度方面优于ERG。NPX组患者倾向于使用较少的急救药物。NPX或ERG治疗的患者报告的副作用频率没有显著差异。这项研究表明，NPX与ERG一样安全，在急性偏头痛发作中略更有效（尽管差异无统计学意义），并且偏头痛患者在治疗急性偏头痛头痛时倾向于更喜欢NPX而非ERG。
