Johnson E S, Ratcliffe D M, Wilkinson M
Cephalalgia. 1985 Mar;5(1):5-10. doi: 10.1046/j.1468-2982.1985.0501005.x.
Seventy patients with classical or common migraine were treated during their attacks with either naproxen sodium or placebo in a randomised, double-blind parallel group study. The initial dose of naproxen sodium was 825 mg followed one hour later by a further 550 mg, if symptoms were the same or had improved. If the migraine symptoms had worsened, patients were offered an escape analgesic combination of 1000 mg paracetamol and 10 mg metoclopramide. Patients were assessed at monthly intervals for changes in the severity and duration of headache, premonitory symptoms (mainly visual disturbances) and photophobia, nausea and vomiting associated with migraine attacks that had occurred since the previous visit. Patients were studied for a maximum of ten attacks and significant improvement was observed in the severity and duration of headache when the patients were on naproxen sodium. Also the premonitory symptoms and photophobia improved significantly on naproxen sodium and significantly less rescue analgesics were required. Patients suffering from common migraine had less severe headaches and photophobia when taking naproxen sodium than when taking placebo and the headaches were shorter in duration and patients took less rescue analgesic. No significant difference was observed between the treatment groups in patients with classical migraine. Ten patients in the placebo group and six in the naproxen sodium group reported side-effects but these were possibly related to the use of rescue medication. Naproxen sodium proved safe and effective in common migraine attacks, but in this study efficacy was not established for classical migraine.
在一项随机、双盲平行组研究中，70例患有典型偏头痛或普通偏头痛的患者在发作期间接受了萘普生钠或安慰剂治疗。萘普生钠的初始剂量为825毫克，一小时后若症状相同或有所改善，则再服用550毫克。若偏头痛症状恶化，则为患者提供1000毫克对乙酰氨基酚和10毫克甲氧氯普胺的解救镇痛组合。每隔一个月对患者进行评估，以了解自上次就诊以来发生的偏头痛发作的头痛严重程度和持续时间、先兆症状（主要是视觉障碍）以及畏光、恶心和呕吐的变化。对患者进行最多十次发作的研究，结果发现患者服用萘普生钠时，头痛的严重程度和持续时间有显著改善。此外，萘普生钠还能显著改善先兆症状和畏光，且所需的解救镇痛药明显减少。患有普通偏头痛的患者服用萘普生钠时的头痛严重程度和畏光程度低于服用安慰剂时，头痛持续时间更短，服用的解救镇痛药也更少。在典型偏头痛患者中，各治疗组之间未观察到显著差异。安慰剂组有10名患者、萘普生钠组有6名患者报告了副作用，但这些副作用可能与使用解救药物有关。萘普生钠在普通偏头痛发作中被证明是安全有效的，但在本研究中，其对典型偏头痛的疗效尚未得到证实。
