Pradalier A, Rancurel G, Dordain G, Verdure L, Rascol A, Dry J
Cephalalgia. 1985 Jun;5(2):107-13. doi: 10.1046/j.1468-2982.1985.0502107.x.
The efficacy of safety of naproxen sodium and ergotamine tartrate were compared for the treatment of acute migraine attack in a randomized, parallel trial with 114 participating patients. At the start of symptoms, patients took either three tablets of naproxen sodium (275 mg each) or one of an ergotamine combination (containing 2 mg ergotamine tartrate, 91.5 mg caffeine, and 50 mg cyclizine chlorhydrate). Patients were followed for three months or until six attacks were monitored, whichever came first. Both medications substantially shortened the duration of migraine attacks and reduced the severity of symptoms. When the test medications were taken within 2 h of onset of attack, naproxen sodium was statistically significantly more effective than the ergotamine combination in reducing the severity of headache pain, nausea, and lightheadedness. The ergotamine combination was associated with significantly more vomiting, need for rescue medication, and side effects than was naproxen sodium. Four patients required discontinuation of the ergotamine combination and one of naproxen sodium. Both patients and investigators rated tolerance for naproxen sodium as superior to tolerance for the ergotamine combination. Naproxen sodium seems to be an effective and safe treatment for migraine attacks.
在一项有114名参与患者的随机平行试验中，比较了萘普生钠和酒石酸麦角胺治疗急性偏头痛发作的疗效和安全性。在症状开始时，患者服用三片萘普生钠（每片275毫克）或一种麦角胺复方制剂（含2毫克酒石酸麦角胺、91.5毫克咖啡因和50毫克盐酸赛克利嗪）。对患者随访三个月，或直至监测到六次发作，以先到者为准。两种药物均显著缩短了偏头痛发作的持续时间并减轻了症状的严重程度。当在发作开始后2小时内服用试验药物时，萘普生钠在减轻头痛疼痛、恶心和头晕的严重程度方面比麦角胺复方制剂在统计学上更有效。麦角胺复方制剂比萘普生钠有更多的呕吐、需要使用急救药物和副作用。四名患者需要停用麦角胺复方制剂，一名患者需要停用萘普生钠。患者和研究者都认为萘普生钠的耐受性优于麦角胺复方制剂。萘普生钠似乎是一种治疗偏头痛发作的有效且安全的药物。
