9-四氢大麻酚和大麻二酚对大鼠大脑皮层制备的突触小泡Mg2+-ATP酶的影响。
Effects of delta9-tetrahydrocannabinol and cannabidiol on a Mg2+-ATPase of synaptic vesicles prepared from rat cerebral cortex.
作者信息
Gilbert J C, Pertwee R G, Wyllie M G
出版信息
Br J Pharmacol. 1977 Apr;59(4):599-601. doi: 10.1111/j.1476-5381.1977.tb07727.x.
Abstract
- delta9-Tetrahydrocannabinol and cannabidiol both exhibited a concentration-related inhibition of Mg2+-ATPase of vesicles prepared from synaptosomes isolated from rat cerebral cortex. Cannabidiol was about 3 times more potent than tetrahydrocannabinol. 2. These results were similar to those obtained previously using drugs with well established anticonvulsant activity. 3. Tetrahydrocannabinol at a sub-inhibitory concentration (1 micronM) increased the activity of the Mg2+-ATPase relative to values obtained with vehicle controls.
摘要
- Δ9-四氢大麻酚和大麻二酚对从大鼠大脑皮层分离的突触体所制备的囊泡的Mg2+-ATP酶均表现出浓度相关的抑制作用。大麻二酚的效力约为四氢大麻酚的3倍。2. 这些结果与先前使用具有公认抗惊厥活性的药物所获得的结果相似。3. 相对于载体对照所获得的值，亚抑制浓度（1微摩尔）的四氢大麻酚增加了Mg2+-ATP酶的活性。
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