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本文引用的文献

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Pharmacokinetics of Phytocannabinoid Acids and Anticonvulsant Effect of Cannabidiolic Acid in a Mouse Model of Dravet Syndrome.植物大麻素酸的药代动力学和大麻二酚酸在 Dravet 综合征小鼠模型中的抗惊厥作用。
J Nat Prod. 2019 Nov 22;82(11):3047-3055. doi: 10.1021/acs.jnatprod.9b00600. Epub 2019 Nov 5.
2
Coadministered cannabidiol and clobazam: Preclinical evidence for both pharmacodynamic and pharmacokinetic interactions.联合给予大麻二酚和氯巴占:药效学和药代动力学相互作用的临床前证据。
Epilepsia. 2019 Nov;60(11):2224-2234. doi: 10.1111/epi.16355. Epub 2019 Oct 17.
3
Absence of Entourage: Terpenoids Commonly Found in Do Not Modulate the Functional Activity of Δ-THC at Human CB and CB Receptors.无伴随物:大麻中常见的萜类化合物不会调节Δ-THC在人CB1和CB2受体上的功能活性。
Cannabis Cannabinoid Res. 2019 Sep 23;4(3):165-176. doi: 10.1089/can.2019.0016. eCollection 2019.
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Probing the antioxidant activity of Δ-tetrahydrocannabinol and cannabidiol in Cannabis sativa extracts.探究大麻提取物中 Δ-四氢大麻酚和大麻二酚的抗氧化活性。
Analyst. 2019 Aug 5;144(16):4952-4961. doi: 10.1039/c9an00890j.
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Cannabidiol inhibits sucrose self-administration by CB1 and CB2 receptor mechanisms in rodents.大麻二酚通过啮齿动物的 CB1 和 CB2 受体机制抑制蔗糖的自我给药。
Addict Biol. 2020 Jul;25(4):e12783. doi: 10.1111/adb.12783. Epub 2019 Jun 19.
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A Survey of Hospice Professionals Regarding Medical Cannabis Practices. Hospice 专业人员医疗大麻实践情况调查。
J Palliat Med. 2019 Oct;22(10):1208-1212. doi: 10.1089/jpm.2018.0535. Epub 2019 May 16.
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Terpenes in Cannabis sativa - From plant genome to humans.大麻中的萜烯——从植物基因组到人类。
Plant Sci. 2019 Jul;284:67-72. doi: 10.1016/j.plantsci.2019.03.022. Epub 2019 Apr 4.
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Pharmacokinetics and Tolerability of Multiple Doses of Pharmaceutical-Grade Synthetic Cannabidiol in Pediatric Patients with Treatment-Resistant Epilepsy.药物治疗抵抗性癫痫患儿多次使用医药级合成大麻素的药代动力学和耐受性。
CNS Drugs. 2019 Jun;33(6):593-604. doi: 10.1007/s40263-019-00624-4.
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Chemotherapy-induced cachexia dysregulates hypothalamic and systemic lipoamines and is attenuated by cannabigerol.化疗诱导的恶病质会扰乱下丘脑和全身的脂肪胺,而大麻萜酚则可以减轻这种影响。
J Cachexia Sarcopenia Muscle. 2019 Aug;10(4):844-859. doi: 10.1002/jcsm.12426. Epub 2019 Apr 29.
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Quantitative determination of CBD and THC and their acid precursors in confiscated cannabis samples by HPLC-DAD.采用高效液相色谱-二极管阵列检测器(HPLC-DAD)对没收大麻样品中的大麻二酚(CBD)、四氢大麻酚(THC)及其酸性前体进行定量测定。
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药物更广泛应用的障碍。

Barriers to the wider adoption of medicinal .

作者信息

Alexander Stephen Ph

机构信息

School of Life Sciences, University of Nottingham Medical School, Nottingham, UK.

出版信息

Br J Pain. 2020 May;14(2):122-132. doi: 10.1177/2049463720922884. Epub 2020 May 29.

DOI:10.1177/2049463720922884
PMID:32537151
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7265599/
Abstract

The use of -based preparations for medicinal use has waxed and waned in the multi-millennial history of human co-existence with the plant and its cultivation. Recorded use of preparations from is effectively as old as recorded history with examples from China, India and Ancient Egypt. Prohibition and restriction of availability allowed a number of alternatives to take the place of preparations. However, there has been a worldwide resurgence in medicinal advocacy from the public. Media interest has been piqued by particular evocative cases. Altogether, therefore, there is pressure on healthcare professionals to prescribe and dispense -based preparations. This review enunciates some of the barriers which are slowing the wider adoption of medicinal .

摘要

在人类与该植物及其种植共存的数千年历史中,药用[植物名称]制剂的使用经历了兴衰起伏。有记录的对[植物名称]制剂的使用几乎与有记录的历史一样古老,中国、印度和古埃及都有相关例证。对其可用性的禁止和限制使得多种替代物取代了[植物名称]制剂。然而,公众对药用[植物名称]的支持在全球范围内再度兴起。一些特别引人关注的案例激发了媒体的兴趣。因此,总体而言,医疗保健专业人员面临着开具和调配基于[植物名称]的制剂的压力。本综述阐明了一些阻碍药用[植物名称]更广泛应用的障碍。