[进行性系统性硬化症和局限性硬皮病家族性发病的免疫遗传学研究]
[Immunogenetic studies of familial occurrence of progressive systemic scleroderma and circumscribed scleroderma].
作者信息
Holzmann H, Schlieter A, Altmeyer P, Kühnl P
机构信息
Abteilung I, Johann-Wolfgang-Goethe-Universität Frankfurt/Main.
出版信息
Hautarzt. 1992 Sep;43(9):548-53.
PMID:1399599
Abstract
Two different forms of scleroderma in one family are described: the mother suffers from systemic sclerosis and her daughter from linear morphoea. The observed HLA antigens indicate that systemic sclerosis and morphoea have various features in common. The immunogenetic data can be used to calculate the aetiological and preventive fractions, which together with environmental hazards and other risk factors describe the HLA-associated potential for provocation of scleroderma.
摘要
本文描述了一个家族中两种不同形式的硬皮病
母亲患有系统性硬化症，女儿患有线状硬斑病。观察到的 HLA 抗原表明，系统性硬化症和硬斑病有多种共同特征。免疫遗传学数据可用于计算病因学和预防分数，这些分数与环境危害和其他风险因素一起描述了 HLA 相关的硬皮病诱发潜力。
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