[天然肝癌致癌物黄樟素不同类似物和代谢物在培养大鼠肝细胞中的代谢比较研究]
[A comparative study in cultured rat liver cells of the metabolism of different analogues and metabolites of a natural hepatocarcinogen: safrol].
作者信息
Janiaud P, Delaforge M, Levi P, Maume B F, Padieu P
出版信息
C R Seances Soc Biol Fil. 1976;170(5):1035-41.
PMID:139975
Abstract
Metabolism by sexed rat liver cell lines of safrole, a natural hepatocancerogen and of metabolites and analogs were studied and compared by gas chromatography-mass spectrometry. The epoxide-diol route was evidenced for safrole, isosafrole and eugenol as well as the induction of drug metabolizing enzymes by tested compounds.
摘要
通过气相色谱-质谱联用技术，对天然肝癌致癌物黄樟素及其代谢产物和类似物在不同性别的大鼠肝细胞系中的代谢情况进行了研究和比较。结果表明，黄樟素、异黄樟素和丁香酚均通过环氧化物-二醇途径代谢，并且受试化合物可诱导药物代谢酶的产生。
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