乳酸乳球菌乳酸亚种中的支链氨基酸生物合成基因。
Branched-chain amino acid biosynthesis genes in Lactococcus lactis subsp. lactis.
作者信息
Godon J J, Chopin M C, Ehrlich S D
机构信息
Laboratoire de Génétique Microbienne, Institut National de la Recherche Agronomique, Jouy-en-Josas, France.
出版信息
J Bacteriol. 1992 Oct;174(20):6580-9. doi: 10.1128/jb.174.20.6580-6589.1992.
Abstract
The genes for biosynthesis of the branched-chain amino acids leucine, isoleucine, and valine in Lactococcus lactis subsp. lactis NCDO2118 were characterized by cloning, complementation in Escherichia coli and Bacillus subtilis, and nucleotide sequence analysis. Nine structural genes are clustered on a 12-kb DNA fragment in the order leuABCD ilvDBNCA. Upstream of these genes, the nucleotide sequence suggests the existence of regulation by transcriptional attenuation. Between the leuD and ilvD genes is an unexpected gene, encoding a protein which belongs to the ATP-binding cassette protein superfamily.
摘要
乳酸乳球菌乳亚种NCDO2118中支链氨基酸亮氨酸、异亮氨酸和缬氨酸生物合成的基因通过克隆、在大肠杆菌和枯草芽孢杆菌中的互补以及核苷酸序列分析进行了表征。九个结构基因以leuABCD ilvDBNCA的顺序聚集在一个12 kb的DNA片段上。在这些基因的上游，核苷酸序列表明存在转录衰减调控。在leuD和ilvD基因之间是一个意外的基因，编码一种属于ATP结合盒蛋白超家族的蛋白质。
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