Marcus M L, Eckberg D L, Braxmeier J L, Abboud F M
Circ Res. 1977 May;40(5):484-8. doi: 10.1161/01.res.40.5.484.
Although the effects of persistent pressure loading on the development of ventricular hypertrophy have been studied extensively, the effects of intermittent pressure loading have not been examined. To study the effects of intermittent pressure loading we subjected the right ventricle of cats to intermittent pulmonary artery constriction over a 2-week period. Two intermittent pressure loading schedules were employed. The first consisted of a right ventricular systolic pressure of 60 mm Hg for 3.5 days and normal right ventricular pressure for 3.5 days; and the second consisted of a right ventricular systolic pressure of 60 mm Hg for 2.3 days and normal right ventricular pressure for 4.7 days. The intermittent pressure-loaded cats were compared with normal unoperated controls, sham-operated controls, and cats with persistent right ventricular pressure load for either 1-week or 1- to 2-month duration. The data indicate that intermittent pressure loading caused significant right ventricular hypertrophy. Since significant residual ventricular hypertrophy was present in both intermittent pressure loading groups, regression of ventricular hypertrophy involves a slower process than the progression of hypertrophy.
尽管持续压力负荷对心室肥厚发展的影响已得到广泛研究，但间歇性压力负荷的影响尚未得到研究。为了研究间歇性压力负荷的影响，我们在2周的时间内对猫的右心室进行间歇性肺动脉缩窄。采用了两种间歇性压力负荷方案。第一种方案是右心室收缩压为60 mmHg持续3.5天，然后是正常右心室压力持续3.5天；第二种方案是右心室收缩压为60 mmHg持续2.3天，然后是正常右心室压力持续4.7天。将间歇性压力负荷的猫与正常未手术对照组、假手术对照组以及右心室持续压力负荷1周或1至2个月的猫进行比较。数据表明，间歇性压力负荷导致了显著的右心室肥厚。由于两个间歇性压力负荷组均存在显著的残余心室肥厚，心室肥厚的消退过程比肥厚的进展过程更为缓慢。
