一种用于鉴别和分离强毒和减毒脊髓灰质炎病毒的铝标记物。
An aluminum marker for the differentiation and separation of virulent and attenuated polioviruses.
作者信息
WALLIS C, MELNICK J L, FERRY G D, WIMBERLY I L
出版信息
J Exp Med. 1962 Apr 1;115(4):763-75. doi: 10.1084/jem.115.4.763.
Abstract
A new character, the A marker, for polioviruses is described. In the presence of Al(+++) (1 to 100 mM) attenuated, but not virulent, strains of type 1 and type 2 polioviruses are stabilized so that they resist thermal inactivation at 50 degrees C. Differences between the attenuated and virulent type 3 strains studied were of the opposite character and less marked. By the use of optimal concentrations of Al(+++) (12 mM for type 1 and 1 mM for type 2) attenuated strains can be separated from mixtures containing virulent type 1 or 2 strains. The A marker was found to be correlated with the d but not the rct/40 or T marker. The A marker has been used for following genetic changes of vaccine strains after their multiplication in man.
摘要
本文描述了脊髓灰质炎病毒的一种新特性——A标记。在存在Al(+++)（1至100 mM）的情况下，1型和2型脊髓灰质炎病毒的减毒株而非强毒株会被稳定化，从而能够抵抗50℃的热灭活。所研究的3型减毒株和强毒株之间的差异性质相反且不太明显。通过使用最佳浓度的Al(+++)（1型为12 mM，2型为1 mM），可以从含有1型或2型强毒株的混合物中分离出减毒株。发现A标记与d相关，但与rct/40或T标记无关。A标记已被用于追踪疫苗株在人体中增殖后的基因变化。
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