Andersen J V, Hansen S H
PharmaBiotec Research Center, Royal Danish School of Pharmacy, Department of Organic Chemistry, Copenhagen.
J Chromatogr. 1992 Jun 10;577(2):362-5. doi: 10.1016/0378-4347(92)80260-w.
A high-performance liquid chromatographic method for the simultaneous determination of both enantiomers of naproxen and its metabolite 6-O-desmethylnaproxen has been developed. The separation is performed on a column containing alpha 1-acid glycoprotein as the chiral selector. The method has been used for the determination of the enantiomeric purity of the drug substance and the metabolite, and for the simultaneous determination of all four compounds in biological fluids.
已开发出一种高效液相色谱法，用于同时测定萘普生及其代谢物6-O-去甲基萘普生的两种对映体。分离在含有α1-酸性糖蛋白作为手性选择剂的柱上进行。该方法已用于测定原料药和代谢物的对映体纯度，以及同时测定生物流体中的所有四种化合物。
