Dorizzi R, Michelot D, Tagliaro F, Ghielmi S
Clinical Chemistry Laboratory, Hospital of Legnago, Italy.
J Chromatogr. 1992 Sep 16;580(1-2):279-91. doi: 10.1016/0378-4347(92)80539-3.
Methods for the chromatographic determination of amanitins, toxins of Amanita phalloides (Fr.), Link mushrooms and related toxins are reviewed; particular emphasis is given to high-performance liquid chromatographic methods. The main chemical and toxicological aspects are discussed, but the focus of the present review is on the analytical problems arising in a laboratory charged with the setting up of a procedure which can direct the appropriate clinical management of an intoxicated patient or solve a forensic case.
综述了用于色谱测定鹅膏毒素、毒鹅膏(毒蝇伞,弗里斯)毒素及相关毒素的方法;特别强调了高效液相色谱法。文中讨论了主要的化学和毒理学方面,但本综述的重点是在一个负责建立能指导中毒患者适当临床处理或解决法医案件程序的实验室中出现的分析问题。