Wada I, Matson P L, Horne G, Buck P, Lieberman B A
Regional IVF Unit, St Mary's Hospital, Manchester, UK.
Hum Reprod. 1992 Sep;7(8):1090-3. doi: 10.1093/oxfordjournals.humrep.a137798.
A total of 28 women scheduled for in-vitro fertilization used buserelin and human menopausal gonadotrophin (HMG) for ovarian stimulation. One group (I) of 17 women was given human chorionic gonadotrophin (HCG 10,000 IU) to trigger ovulation, but the resulting embryos were electively cryopreserved because of the risk (serum oestradiol greater than or equal to 3500 pg/ml) of developing the ovarian hyperstimulation syndrome (OHSS). Six women continued the buserelin therapy in the luteal phase and eleven did not. In group II (n = 11), the HMG injections were discontinued because of an exaggerated ovarian response and the HCG was omitted. Six of these women continued the buserelin injections until the onset of menses and five did not. In both groups, the ovarian response to induction of ovulation (serum oestradiol concentrations and number of follicles) was similar for those who did or did not continue buserelin therapy. There was no difference in the rate of ovarian quiescence (weekly fall in serum oestradiol concentration following the stimulation) between those women who did or did not continue the buserelin therapy in either group. The serum luteinizing hormone concentrations remained low in all women in both groups. We conclude that the omission of buserelin therapy after discontinuing the HMG in women at risk of developing OHSS does not affect subsequent ovarian quiescence.
共有28名计划接受体外受精的女性使用布舍瑞林和人绝经期促性腺激素（HMG）进行卵巢刺激。17名女性组成的第一组（I组）给予人绒毛膜促性腺激素（HCG 10,000 IU）以触发排卵，但由于存在发生卵巢过度刺激综合征（OHSS）的风险（血清雌二醇大于或等于3500 pg/ml），所产生的胚胎被选择性冷冻保存。6名女性在黄体期继续布舍瑞林治疗，11名则未继续。在第二组（n = 11）中，由于卵巢反应过度，HMG注射停止且未使用HCG。这些女性中有6名继续注射布舍瑞林直至月经来潮，5名则未继续。在两组中，继续或不继续布舍瑞林治疗的女性对排卵诱导的卵巢反应（血清雌二醇浓度和卵泡数量）相似。两组中继续或不继续布舍瑞林治疗的女性之间，卵巢静止率（刺激后血清雌二醇浓度的每周下降）没有差异。两组所有女性的血清黄体生成素浓度均保持较低水平。我们得出结论，对于有发生OHSS风险的女性，在停止HMG治疗后省略布舍瑞林治疗不会影响随后的卵巢静止。
