van der Meer S, Gerris J, Joostens M, Tas B
Department of Obstetrics, Gynaecology and Fertility, Middelheim Hospital, Antwerpen, Belgium.
Hum Reprod. 1993 Oct;8(10):1628-31. doi: 10.1093/oxfordjournals.humrep.a137903.
A total of 24 women with primary or secondary infertility due to oligo- or anovulation, were treated with human menopausal gonadotrophin (HMG). In 48 cycles, we used a gonadotrophin-releasing hormone agonist (GnRHa) nasal spray (buserelin) to induce a pre-ovulatory endogenous luteinizing hormone (LH) surge. In 44 cycles, there was a rapid rise of the serum LH concentration within 8 h from the first administration of GnRHa. One patient with pituitary hypogonadotrophic amenorrhoea showed a weak or no response in four treatment cycles. Conception occurred in 10 cycles (pregnancy/cycle (P/C) index = 22.7%), four of which ended in a spontaneous abortion and six of which are ongoing pregnancies. In 27 cycles, there was an increased risk for ovarian hyperstimulation syndrome (OHSS), defined as more than three follicles > or = 18 mm in diameter and/or serum oestradiol > 1200 pg/ml. Three of these treatment cycles gave rise to the development of moderate OHSS in the absence of exogenously administered human chorionic gonadotrophin, two being conception cycles.
共有24名因排卵过少或无排卵导致原发性或继发性不孕的女性接受了人绝经期促性腺激素（HMG）治疗。在48个周期中，我们使用促性腺激素释放激素激动剂（GnRHa）鼻喷雾剂（布舍瑞林）诱导排卵前内源性黄体生成素（LH）峰。在44个周期中，从首次给予GnRHa起8小时内血清LH浓度迅速升高。1例垂体性低促性腺激素性闭经患者在4个治疗周期中反应微弱或无反应。10个周期受孕（妊娠/周期（P/C）指数=22.7%），其中4例以自然流产告终，6例为持续妊娠。在27个周期中，卵巢过度刺激综合征（OHSS）风险增加，定义为直径大于或等于18 mm的卵泡超过3个和/或血清雌二醇大于1200 pg/ml。在这些治疗周期中，有3个在未给予外源性人绒毛膜促性腺激素的情况下发展为中度OHSS，其中2个为受孕周期。
