Smitz J, Van Den Abbeel E, Bollen N, Camus M, Devroey P, Tournaye H, Van Steirteghem A C
Centre for Reproductive Medicine, Vrije Universiteit Brussel, Belgium.
Hum Reprod. 1992 Sep;7(8):1098-102. doi: 10.1093/oxfordjournals.humrep.a137800.
Sixty-three normo-ovulatory infertile women were randomly divided into two groups. All women were first desensitized with the gonadotrophin-releasing hormone agonist (GnRHa), buserelin. Thereafter, ovarian stimulation with human menopausal gonadotrophins (HMG) was started in both groups but in group A the GnRHa was stopped on the same day. In group B, the GnRHa was continued during HMG treatment until the ovulatory human chorionic gonadotrophin stimulus was given. Premature luteinization was not observed in either group, although the preovulatory basal luteinizing hormone (LH) secretion was significantly higher in group A. An equal number of embryos of comparable quality was transferred in both groups and the pregnancy outcome was similar. However, the supernumerary embryos of group A were of a lower morphological quality and survived the cryopreservation process less well. We concluded that the continuous administration of a GnRH agonist during HMG treatment resulted in better quality of supernumerary embryos.
63名排卵正常的不孕女性被随机分为两组。所有女性首先用促性腺激素释放激素激动剂（GnRHa）布舍瑞林进行脱敏。此后，两组均开始用人绝经期促性腺激素（HMG）进行卵巢刺激，但A组在同一天停用GnRHa。在B组中，GnRHa在HMG治疗期间持续使用，直到给予促排卵的人绒毛膜促性腺激素刺激。两组均未观察到过早黄素化，尽管A组排卵前基础促黄体生成素（LH）分泌显著更高。两组移植了数量相等、质量相当的胚胎，妊娠结局相似。然而，A组的多余胚胎形态质量较低，在冷冻保存过程中的存活率也较低。我们得出结论，在HMG治疗期间持续给予GnRH激动剂可使多余胚胎的质量更好。
