Madhok R, Cruickshank A, Gracie A J, Shenkin A, Lowe G D
University Department of Medicine, Glasgow Royal Infirmary.
J Clin Pathol. 1992 Sep;45(9):766-9. doi: 10.1136/jcp.45.9.766.
To measure IL-6 concentrations in asymptomatic HIV-1 antibody positive and negative haemophilic patients and to correlate these with IgG concentrations and CD4 positive cell numbers.
IL-6 concentrations were measured by bioassay in stored serum from a prospective cohort of haemophilic patients in whom immunoglobulins and T cell subsets had been determined. Values of IL-6 and immunoglobulins were also correlated with severity of liver disease.
IL-6 concentrations were raised in haemophilic patients independent of HIV-1 antibody status. In HIV-1 antibody positive patients there was no correlation between IL-6 concentrations and CD4 positive cell numbers, but there was a correlation with IgG (r = 0.4; p = 0.05). In HIV-1 antibody negative patients there were no significant correlations.
Haemophilic patients have increased IL-6 concentrations; in HIV-1 positive patients this is independent of the decline in CD4 cell count. The raised concentrations do not correlate with the clinical severity of liver disease.
检测无症状的HIV-1抗体阳性和阴性血友病患者体内白细胞介素-6(IL-6)的浓度,并将其与免疫球蛋白G(IgG)浓度及CD4阳性细胞数量进行关联分析。
通过生物测定法检测来自一个前瞻性血友病患者队列的储存血清中的IL-6浓度,这些患者的免疫球蛋白和T细胞亚群已被测定。IL-6和免疫球蛋白的值也与肝病严重程度相关联。
血友病患者体内的IL-6浓度升高,与HIV-1抗体状态无关。在HIV-1抗体阳性患者中,IL-6浓度与CD4阳性细胞数量之间无相关性,但与IgG存在相关性(r = 0.4;p = 0.05)。在HIV-1抗体阴性患者中,无显著相关性。
血友病患者的IL-6浓度升高;在HIV-1阳性患者中,这与CD4细胞计数的下降无关。升高的浓度与肝病的临床严重程度无关。