Erhan Y, Toprak A S, Ozdemir N, Tiras B
Obstetrics and Gynaecology Department, Ege University Medical Faculty, Bornova, Turkey.
J Clin Pathol. 1992 Sep;45(9):828-9. doi: 10.1136/jcp.45.9.828.
Most patients with gonadoblastoma have dysgenetic gonads. This rare tumour has been described in three pregnant women. A fourth case in a 26 year old pregnant woman who presented with gonadoblastoma and dysgerminoma, is reported. She had a normal term pregnancy, 46XX chromosomes, normal genitalia, no history of menstrual irregularities and no signs of hyperandrogenism, thereby differing from the other reported cases. The germ cell component of this patient's tumour had undergone rapid overgrowth, most of the tumour comprising pure dysgerminoma. It is suggested that gonadoblastoma may occur in functionally and morphologically normal gonads more often than previous case reports imply.
大多数性腺母细胞瘤患者存在性腺发育不全。这种罕见肿瘤在三名孕妇中被描述过。本文报告了一名26岁孕妇的第四例病例，该孕妇患有性腺母细胞瘤和无性细胞瘤。她足月妊娠，染色体核型为46XX，生殖器正常，无月经不规律病史，也无高雄激素血症迹象，因此与其他报告病例不同。该患者肿瘤的生殖细胞成分迅速过度生长，大部分肿瘤为单纯无性细胞瘤。提示性腺母细胞瘤可能比以往病例报告所暗示的更常发生于功能和形态正常的性腺中。
