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一名46,XY个体的双侧性腺母细胞瘤/无性细胞瘤：病例报告及激素研究

Bilateral gonadoblastoma/dysgerminoma in a 46 XY individual: case report with hormonal studies.

作者信息

Fisher R A, Salm R, Spencer R W

出版信息

J Clin Pathol. 1982 Apr;35(4):420-4. doi: 10.1136/jcp.35.4.420.

DOI:10.1136/jcp.35.4.420
PMID:7076870
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC497673/
Abstract

A case of bilateral gonadoblastoma/dysgerminoma in a 46 XY phenotypical female is presented. Increased circulating beta human chorionic gonadotropin (beta-HCG) and testosterone together with a decreased concentration of follicle stimulating hormone (FSH) reflected the activities of these tumours. The patient is alive and well three years later, after treatment by surgery and cobalt therapy.

摘要

本文报告一例46 XY表型女性双侧性腺母细胞瘤/无性细胞瘤病例。循环血中β人绒毛膜促性腺激素（β-HCG）和睾酮水平升高，同时促卵泡激素（FSH）浓度降低，反映了这些肿瘤的活性。该患者在接受手术和钴治疗后三年，目前仍健在且状况良好。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89ac/497673/4b7b4d158fc3/jclinpath00497-0054-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89ac/497673/a55ff2b0bd26/jclinpath00497-0053-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89ac/497673/f2daf13a5b9e/jclinpath00497-0053-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89ac/497673/4b7b4d158fc3/jclinpath00497-0054-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89ac/497673/a55ff2b0bd26/jclinpath00497-0053-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89ac/497673/f2daf13a5b9e/jclinpath00497-0053-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89ac/497673/4b7b4d158fc3/jclinpath00497-0054-a.jpg

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Bilateral gonadoblastoma/dysgerminoma in a 46 XY individual: case report with hormonal studies.一名46,XY个体的双侧性腺母细胞瘤/无性细胞瘤：病例报告及激素研究
J Clin Pathol. 1982 Apr;35(4):420-4. doi: 10.1136/jcp.35.4.420.
2
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引用本文的文献

1
Comparison of adult height between patients with XX and XY gonadal dysgenesis: support for a Y specific growth gene(s).XX和XY性腺发育不全患者成人身高的比较：对Y染色体特异性生长基因的支持。
J Med Genet. 1992 Aug;29(8):539-41. doi: 10.1136/jmg.29.8.539.
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Gonadoblastoma and fertility.性腺母细胞瘤与生育能力。
J Clin Pathol. 1992 Sep;45(9):828-9. doi: 10.1136/jcp.45.9.828.

本文引用的文献

1
Mixed germ cell tumours (gonadoblastomas) in normal and dysgenetic gonads. Case reports and review.正常及发育异常性腺中的混合性生殖细胞肿瘤（性腺母细胞瘤）。病例报告及文献复习
Virchows Arch A Pathol Pathol Anat. 1970;349(3):258-80. doi: 10.1007/BF00544577.
2
Suppressed follicle stimulating hormone in men with chorionic gonadotropin secreting testicular tumors.绒毛膜促性腺激素分泌性睾丸肿瘤男性患者促卵泡生成素受抑制
J Clin Endocrinol Metab. 1971 Dec;33(6):957-61. doi: 10.1210/jcem-33-6-957.
3
[Letter: 46 XY gonadal dysgenesis. A case with normal estrogen elimination, elevated gonadotropins and ovarian vestiges].
[信件：46，XY性腺发育不全。一例雌激素清除正常、促性腺激素升高且存在卵巢遗迹的病例]
Nouv Presse Med. 1973 Nov 24;2(42):2822.
4
Suppressed follicle-stimulating hormone (FSH) in women with gestational trophoblastic neoplasms.妊娠滋养细胞肿瘤女性中促卵泡生成素（FSH）受到抑制。
J Clin Endocrinol Metab. 1973 Apr;36(4):697-701. doi: 10.1210/jcem-36-4-697.
5
Gonadoblastoma in a true hermaphrodite with 46, XY genotype.46,XY基因型真两性畸形中的性腺母细胞瘤
Obstet Gynecol. 1972 Oct;40(4):466-72.
6
A possible explanation for spontaneous breast development in XY gonadal dysgenesis.XY性腺发育不全中乳房自发发育的一种可能解释。
Ann Endocrinol (Paris). 1972 Sep-Oct;33(5):517-22.
7
Pure gonadal dysgenesis with progressive hirsutism.伴有进行性多毛症的单纯性腺发育不全。
N Engl J Med. 1970 Apr 16;282(16):881-5. doi: 10.1056/NEJM197004162821601.
8
A comparison of two methods for the separate estimation of 11-deoxy and 11-oxygenated 17-hydroxycorticosteroids in urine.两种分别测定尿中11-脱氧和11-氧化17-羟皮质类固醇方法的比较。
J Med Lab Technol. 1969 Jul;26(3):243-7.
9
Tumors of dysgenetic gonads (gonadoblastoma): ultrastructural and steroidogenic aspects.
Cancer. 1974 Oct;34(4):1108-25. doi: 10.1002/1097-0142(197410)34:4<1108::aid-cncr2820340422>3.0.co;2-l.
10
C19O2 steroid secretion by dysgenetic gonads.发育不全性腺的C19O2类固醇分泌。
Obstet Gynecol. 1968 Nov;32(5):643-4.