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Extensive bone marrow infarction followed by myelofibrosis in patient with Ph' positive chronic granulocytic leukaemia.Ph'阳性慢性粒细胞白血病患者出现广泛骨髓梗死并继发骨髓纤维化。
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Hematologic remission and cytogenetic improvement induced by recombinant human interferon alpha A in chronic myelogenous leukemia.重组人αA干扰素诱导慢性粒细胞白血病的血液学缓解和细胞遗传学改善。
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Recurrent bone marrow necrosis and extramedullary myeloid deposits in Philadelphia negative chronic myeloid leukaemia.费城染色体阴性慢性髓系白血病中的复发性骨髓坏死和髓外髓样沉积
Haematologica. 1988 Nov-Dec;73(6):513-5.
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Bone marrow necrosis in malignant diseases. A report on seven intravitally recognized cases.恶性疾病中的骨髓坏死。7例经活体检查确诊病例的报告。
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Bone marrow necrosis and degeneration.骨髓坏死与变性。
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Bone marrow necrosis and extramedullary myeloid tumour necrosis in aggressive chronic myeloid leukaemia.侵袭性慢性髓性白血病中的骨髓坏死和髓外髓样肿瘤坏死
Pathology. 1979 Jul;11(3):551-6. doi: 10.3109/00313027909059030.

干扰素治疗慢性粒细胞白血病转化时的骨髓坏死

Bone marrow necrosis at transformation of chronic granulocytic leukaemia treated with interferon.

作者信息

Kendra J R, Pickens S, Singh A K

机构信息

Department of Haematology, Burnley General Hospital, Lancs.

出版信息

J Clin Pathol. 1992 Sep;45(9):830-1. doi: 10.1136/jcp.45.9.830.

DOI:10.1136/jcp.45.9.830
PMID:1401221
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC495118/
Abstract

A patient with chronic myeloid leukaemia was treated with interferon without using conventional cytotoxic agents. Bone marrow necrosis developed at the onset of blast transformation. It is suggested that cytotoxic drugs should be given before treatment with interferon for chronic myeloid leukaemia. Cytotoxic drugs may also be needed to prevent rapid bone marrow growth once interferon has been withdrawn.

摘要

一名慢性髓性白血病患者在未使用传统细胞毒性药物的情况下接受了干扰素治疗。在原始细胞转化开始时发生了骨髓坏死。建议在对慢性髓性白血病进行干扰素治疗之前给予细胞毒性药物。在停用干扰素后，可能也需要细胞毒性药物来防止骨髓快速生长。