干扰素治疗慢性粒细胞白血病转化时的骨髓坏死
Bone marrow necrosis at transformation of chronic granulocytic leukaemia treated with interferon.
作者信息
Kendra J R, Pickens S, Singh A K
机构信息
Department of Haematology, Burnley General Hospital, Lancs.
出版信息
J Clin Pathol. 1992 Sep;45(9):830-1. doi: 10.1136/jcp.45.9.830.
Abstract
A patient with chronic myeloid leukaemia was treated with interferon without using conventional cytotoxic agents. Bone marrow necrosis developed at the onset of blast transformation. It is suggested that cytotoxic drugs should be given before treatment with interferon for chronic myeloid leukaemia. Cytotoxic drugs may also be needed to prevent rapid bone marrow growth once interferon has been withdrawn.
摘要
一名慢性髓性白血病患者在未使用传统细胞毒性药物的情况下接受了干扰素治疗。在原始细胞转化开始时发生了骨髓坏死。建议在对慢性髓性白血病进行干扰素治疗之前给予细胞毒性药物。在停用干扰素后，可能也需要细胞毒性药物来防止骨髓快速生长。
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