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使用α-2b干扰素治疗慢性粒细胞白血病期间的肉芽肿性骨髓炎症。

Granulomatous bone marrow inflammation during treatment of chronic myeloid leukaemia with interferon alpha-2b.

作者信息

Siboni A, Mourits-Andersen T, Moesner J

机构信息

Esbjerg County Hospital, Denmark.

出版信息

J Clin Pathol. 1995 Sep;48(9):878-80. doi: 10.1136/jcp.48.9.878.

DOI:10.1136/jcp.48.9.878
PMID:7490329
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC502884/
Abstract

A patient with chronic myeloid leukaemia developed bone marrow granulomas during treatment with interferon alpha-2b. Some granulomas had necrotic centres and giant cells and there was marked eosinophilia surrounding them. The granulomas disappeared when the interferon treatment was discontinued. Mycobacteriosis was ruled out. The most likely explanation for the granuloma formation was drug hypersensitivity.

摘要

一名慢性髓性白血病患者在接受α-2b干扰素治疗期间出现了骨髓肉芽肿。一些肉芽肿有坏死中心和巨细胞，其周围有明显的嗜酸性粒细胞增多。停用干扰素治疗后，肉芽肿消失。排除了分枝杆菌病。肉芽肿形成的最可能解释是药物超敏反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08b5/502884/1156be4e7c6a/jclinpath00234-0093-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08b5/502884/aaf7c43a472d/jclinpath00234-0093-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08b5/502884/1156be4e7c6a/jclinpath00234-0093-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08b5/502884/aaf7c43a472d/jclinpath00234-0093-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08b5/502884/1156be4e7c6a/jclinpath00234-0093-b.jpg

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本文引用的文献

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Endogenous gamma interferon is essential in granuloma formation induced by glycolipid-containing mycolic acid in mice.内源性γ干扰素在小鼠中由含糖脂的分枝菌酸诱导形成肉芽肿的过程中至关重要。
Infect Immun. 1993 Jul;61(7):2872-8. doi: 10.1128/iai.61.7.2872-2878.1993.
2
Impact of interferon alpha-induced cytogenetic improvement on survival in chronic myelogenous leukaemia.干扰素α诱导的细胞遗传学改善对慢性粒细胞白血病生存的影响。
Br J Haematol. 1993 Mar;83(3):399-403. doi: 10.1111/j.1365-2141.1993.tb04663.x.
3
Interferon-alpha in malignant and viral diseases. A review.
冠状动脉中维生素 D 受体的定量及其与动脉粥样硬化的关系。
Maturitas. 2012 Oct;73(2):143-7. doi: 10.1016/j.maturitas.2012.03.014. Epub 2012 Apr 26.
α干扰素在恶性疾病和病毒性疾病中的应用。综述
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Br J Cancer. 1972 Apr;26(2):120-3. doi: 10.1038/bjc.1972.18.
5
Bone marrow necrosis at transformation of chronic granulocytic leukaemia treated with interferon.干扰素治疗慢性粒细胞白血病转化时的骨髓坏死
J Clin Pathol. 1992 Sep;45(9):830-1. doi: 10.1136/jcp.45.9.830.