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人类狂犬病:80例流行病学及实验室研究

Human rabies: epidemiological and laboratory studies in 80 cases.

作者信息

Madhusudana S N, Aggarwal P

机构信息

Rabies Research Centre, Central Research Institute, Kasauli.

出版信息

J Indian Med Assoc. 1992 Jul;90(7):169-71.

PMID:1401970
Abstract

Epidemiological and laboratory studies were conducted on 80 clinically diagnosed human rabies cases. Incidence of rabies was more in adult males (55%) and boys (37.5%) than adult females (5%) and girls (2.5%) and more in rural areas (76.2%) than urban areas (23.8%). Dogs constituted the main vector of transmission (92.5%). Incomplete course of antirabic vaccine had been received by 31% of cases and 2.5% of cases had complete course of antirabic vaccine. Among the laboratory tests conducted 3.8% of corneal smears and 2.5% of saliva smears were positive by fluorescent antibody technique. Rabies virus was isolated from 3.8% of saliva and 3% of cerebrospinal fluid samples. Rabies neutralising antibody titre ranged from 1:64 to 1:128 in the serum of patients who were fully vaccinated.

摘要

对80例临床诊断的人类狂犬病病例进行了流行病学和实验室研究。狂犬病发病率在成年男性(55%)和男孩(37.5%)中高于成年女性(5%)和女孩(2.5%),在农村地区(76.2%)高于城市地区(23.8%)。狗是主要的传播媒介(92.5%)。31%的病例接受了不完整疗程的抗狂犬病疫苗,2.5%的病例接受了完整疗程的抗狂犬病疫苗。在进行的实验室检测中,3.8%的角膜涂片和2.5%的唾液涂片通过荧光抗体技术呈阳性。从3.8%的唾液和3%的脑脊液样本中分离出狂犬病病毒。在完全接种疫苗的患者血清中,狂犬病中和抗体滴度范围为1:64至1:128。

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