Kasempimolporn S, Sichanasai B, Saengseesom W, Puempumpanich S, Sitprija V
Queen Saovabha Memorial Institute (WHO Collaborating Centerfor Research on Rabies), Thai Red Cross Society, Bangkok, Thailand.
Dev Biol (Basel). 2008;131:137-43.
In Thailand, the animal most reported rabid is the stray dog. Dog bite related rabies cases in humans account for 70-95% of rabies related deaths. The reported incidence of dog bites is highest in the central part of the country, especially in Bangkok. This epidemiological survey shows that at least five different canine rabies virus types are present in Bangkok. Rabies antigen and antibody prevalence in stray dogs in Bangkok was also investigated. Saliva and serum samples were taken from 3,314 stray dogs, captured between December 2003 and June 2004. One two year-old female was antigen positive by latex agglutination test and the result was confirmed by reverse transcription-polymerase chain reaction (RT-PCR). The overall antibody seroprevalence by enzyme-linked immunosorbent assay was 62% (95% CI: 54, 70%). Antibody seroprevalence was higherfor dogs captured within central Bangkok (86% of 1,208 dogs captured) than in the dogs captured on the outskirts of the greater metropolitan area (49% of 2,106 dogs captured). If our sample of stray dogs is representative, then the seroprevalence achieved from previous vaccination campaigns is insufficient in order to break the rabies transmission cycle among stray and feral dogs.
在泰国，报告最多的患狂犬病动物是流浪狗。人类中与狗咬伤相关的狂犬病病例占狂犬病相关死亡病例的70 - 95%。该国中部地区，尤其是曼谷，报告的狗咬伤发生率最高。这项流行病学调查表明，曼谷至少存在五种不同的犬类狂犬病病毒类型。还对曼谷流浪狗的狂犬病抗原和抗体流行情况进行了调查。从2003年12月至2004年6月捕获的3314只流浪狗身上采集了唾液和血清样本。一只两岁雌性流浪狗经乳胶凝集试验抗原呈阳性，结果通过逆转录 - 聚合酶链反应（RT-PCR）得到证实。通过酶联免疫吸附测定法得出的总体抗体血清阳性率为62%（95%置信区间：54, 70%）。在曼谷市中心捕获的狗（1208只捕获狗中的86%）的抗体血清阳性率高于在大市区郊区捕获的狗（2106只捕获狗中的49%）。如果我们的流浪狗样本具有代表性，那么之前疫苗接种活动所达到的血清阳性率不足以打破流浪狗和野狗之间的狂犬病传播循环。
