COSTELLO R, DUBOS R, SCHAEDLER R W
J Exp Med. 1962 Dec 1;116(6):847-57. doi: 10.1084/jem.116.6.847.
NCS mice were found to be susceptible to a hyperacute form of disease induced by injection of relatively large doses of Mycobacterium tuberculosis. Susceptibility to this type of disease was conditioned by the sex, age, and dietary history of the animals. Unlike the more usual response of mice to mycobacterial disease, these conditions affected primarily the relative occurrence of early-acute deaths rather than average survival time. Resistance to this form of disease was increased by previous exposure of the animals to Gram-negative bacteria, to their endotoxin, or to various preparations of killed mycobacterial cells.
发现NCS小鼠对注射相对大剂量结核分枝杆菌诱导的超急性疾病形式敏感。对这种疾病类型的易感性取决于动物的性别、年龄和饮食史。与小鼠对分枝杆菌疾病更常见的反应不同，这些条件主要影响早期急性死亡的相对发生率，而不是平均存活时间。动物先前接触革兰氏阴性菌、其内毒素或各种灭活分枝杆菌细胞制剂可增强对这种疾病形式的抵抗力。
