de Guzman F S, Gloer J B, Wicklow D T, Dowd P F
Department of Chemistry, University of Iowa, Iowa City 52242.
J Nat Prod. 1992 Jul;55(7):931-9. doi: 10.1021/np50085a013.
Three new diketopiperazine-containing metabolites 1-3 have been isolated from the sclerotia of Aspergillus ochraceus (NRRL 3519) by chromatography on Sephadex LH-20 and reversed-phase hplc. The structures of these compounds were established using extensive high-field 1D and 2D nmr experiments. All three compounds cause moderate reduction in weight gain in assays against the lepidopteran crop pest Helicoverpa zea.
通过在Sephadex LH - 20上的色谱法和反相高效液相色谱，从赭曲霉（NRRL 3519）的菌核中分离出三种含二酮哌嗪的新代谢产物1 - 3。利用广泛的高场一维和二维核磁共振实验确定了这些化合物的结构。在针对鳞翅目农作物害虫玉米螟的试验中，所有这三种化合物都会使体重增加适度减少。
