Tian Yong-Qi, Lin Sheng-Nan, Zhou Hong, Lin Shu-Ting, Wang Shao-Yun, Liu Yong-Hong
a College of Biological Science and Technology , Fuzhou University , Fuzhou , China.
b CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology , South China Sea Institute of Oceanology, Chinese Academy of Sciences , Guangzhou , China.
Nat Prod Res. 2018 Nov;32(21):2510-2515. doi: 10.1080/14786419.2017.1423303. Epub 2018 Jan 9.
Two new diketopiperazine alkaloids, named protuboxepin C (1) and protuboxepin D (2), which contain D-Phe residue and oxepin ring, were isolated from EtOAc extract of sponge-derived fungus Aspergillus sp SCSIO XWS02F40. Their structures were elucidated by 1D, 2D NMR and HRESIMS dates, and their absolute configurations were confirmed by single crystal X-ray diffraction experiments and CD analyses. The in vitro cytotoxicity of these two new compounds was further evaluated using A549 and Hela cell lines.
从海绵来源的真菌曲霉属SCSIO XWS02F40的乙酸乙酯提取物中分离出两种新的含有D-苯丙氨酸残基和氧杂环庚三烯环的二酮哌嗪生物碱，分别命名为原盒嗪C（1）和原盒嗪D（2）。通过一维、二维核磁共振和高分辨电喷雾电离质谱数据对其结构进行了鉴定，并通过单晶X射线衍射实验和圆二色光谱分析确定了它们的绝对构型。使用A549和Hela细胞系进一步评估了这两种新化合物的体外细胞毒性。
