KAPLAN M M, PACCAUD M F
Bull World Health Organ. 1963;28(4):495-7.
In an attempt to determine the specific local action of antirabies serum and antirabies gamma-globulin preparations in vivo, experiments were carried out on mice infected with fixed rabies virus in the pad of the foot and then given inoculations of either of these preparations in the same and in the opposite foot at various intervals thereafter.Good evidence was obtained of the local protective effect of antirabies serum and, to a lesser degree, of antirabies gamma-globulin when inoculated one hour after infection. Some protection was also apparent when the inoculations were made up to three hours after infection, but none could be demonstrated at six hours.
为了确定抗狂犬病血清和抗狂犬病γ-球蛋白制剂在体内的具体局部作用，对在脚垫感染固定狂犬病病毒的小鼠进行了实验，随后在不同间隔时间在同一只脚和另一只脚接种这些制剂中的一种。有充分证据表明，感染后1小时接种时，抗狂犬病血清具有局部保护作用，抗狂犬病γ-球蛋白的局部保护作用较弱。感染后3小时内接种也有一定的保护作用，但在6小时时未显示出保护作用。
