Ueda S
Department of Otolaryngology, Toyama Medical and Pharmaceutical University, Faculty of Medicine.
Nihon Jibiinkoka Gakkai Kaiho. 1992 Sep;95(9):1389-97. doi: 10.3950/jibiinkoka.95.1389.
Intravenous lidocaine was administered in 155 cases (196 ears) with tinnitus. The injection of lidocaine, at a dose of 60 mg in men and 40 mg in women was repeated five times. The intensity of tinnitus was evaluated along a scale ranging from 0 to 10, indicating the level prior to injection. A scale ranging from 0 to 7 was estimated to be effective. After evaluation of the drug by using a double-blind test, indications for therapy were analyzed statistically according to clinical characteristics. The results obtained were as follows: 1) The effect was confirmed by using a double-blind test. 2) The effective rate was 60.2%. 3) Older cases, especially with presbyacusis, had the best indications for therapy. 4) From the clinical viewpoint of the characteristics of tinnitus, cases with hearing levels above 40dB or with dull onomatopoeic sounds were considered to have better indications for therapy. 5) None of the side effects experienced were severe, and all were transient.
对155例(196耳)耳鸣患者静脉注射利多卡因。男性利多卡因注射剂量为60毫克,女性为40毫克,重复注射5次。耳鸣强度根据0至10的量表进行评估,该量表表示注射前的水平。估计0至7的量表有效。在通过双盲试验评估药物后,根据临床特征对治疗指征进行统计学分析。获得的结果如下:1)通过双盲试验证实了疗效。2)有效率为60.2%。3)老年患者,尤其是患有老年性聋的患者,治疗指征最佳。4)从耳鸣特征的临床角度来看,听力水平高于40分贝或有沉闷拟声的患者被认为治疗指征较好。5)所经历的副作用均不严重,且均为短暂性。