Hulman G, Trowbridge P, Taylor C N, Chilvers C E, Sloane J P
Department of Histopathology, Royal Marsden Hospital.
J Pathol. 1992 Aug;167(4):407-11. doi: 10.1002/path.1711670410.
A retrospective histopathological study of 300 women under 36 years of age was carried out to determine whether breast cancers occurring in oral contraceptive users showed any differences in pathological features compared with non-users. The patients belong to an age group in which an increased risk of cancer development has been reported following oral contraceptive usage. The incidence of non-neoplastic conditions in the residual breast was also studied in the two groups. There was little difference between breast cancers arising in pill users and non-users but in the residual non-neoplastic breast a decreased incidence of cysts and blunt duct adenosis was found in current users of the contraceptive pill. In contrast, lactational foci were found only in the breasts of pill users. The incidence of intraductal hyperplasia was not significantly different in the two groups.
对300名36岁以下女性进行了一项回顾性组织病理学研究，以确定口服避孕药使用者患乳腺癌的病理特征与非使用者相比是否存在差异。这些患者属于据报道口服避孕药使用后癌症发生风险增加的年龄组。还对两组残余乳腺中的非肿瘤性疾病发病率进行了研究。口服避孕药使用者和非使用者患乳腺癌的情况几乎没有差异，但在残余的非肿瘤性乳腺中，避孕药当前使用者的囊肿和钝性导管腺病发病率降低。相比之下，仅在口服避孕药使用者的乳房中发现了哺乳期病灶。两组导管内增生的发生率没有显著差异。
