Ragni N, Boccardo E, Viglino S, Larosa E
Acta Eur Fertil. 1981 Jun;12(2):141-63.
After a rapid examination of the international literature concerning human, animal, histological and epidemiological experimental data, the Authors state that the use of oral contraceptives considerably reduces the risk of benign disease of the breast. This risk reduction seems to be connected to the presence of progestin in this type of contraception. The Authors then expound the data regarding a group of patients (3527), who came to the center for the diagosis and prevention of cancer of the breast at the S. Martino hospital of Genoa during the years 1977-1980. The results of the study are comparable to those found in international literature, in that they confirm the protective effect of hormonal contraception on benign pathology of the breast. Finally we have shown the data of the retrospective and prospective studies conducted up till now on the effects of hormonal contraception on malignant breast pathology. In conclusion we have shown which lines of study should be taken in order to clarify once and for all the links existing between estroprogestins and cancer of the breast.
在快速查阅了有关人类、动物、组织学和流行病学实验数据的国际文献后，作者指出，使用口服避孕药可显著降低患乳腺良性疾病的风险。这种风险降低似乎与这类避孕方法中孕激素的存在有关。作者随后阐述了一组患者（3527例）的数据，这些患者在1977年至1980年期间前往热那亚圣马蒂诺医院的乳腺癌诊断与预防中心就诊。该研究结果与国际文献中的结果相当，证实了激素避孕对乳腺良性病变的保护作用。最后，我们展示了迄今为止关于激素避孕对乳腺恶性病变影响的回顾性和前瞻性研究数据。总之，我们指出了为彻底阐明雌激素孕激素与乳腺癌之间的现有联系应采取哪些研究方向。
