不同大鼠肿瘤株对二氢卟吩e6光动力治疗的敏感性
Sensitivity of different rat tumour strains to photodynamic treatment with chlorin e6.
作者信息
Kostenich G A, Zhuravkin I N, Furmanchuk A V, Zhavrid E A
机构信息
Department of Chemoradiotherapy, Research Institute of Oncology and Medical Radiology, Minsk, Belarus.
出版信息
J Photochem Photobiol B. 1993 Feb;17(2):187-94. doi: 10.1016/1011-1344(93)80012-x.
Transplantable rat tumours (sarcoma M-1, sarcoma 45, alveolar liver cancer PC-1 and Pliss' lymphosarcoma) were used to study chlorin e6 accumulation in tumours and its photodynamic effect. Tumours were irradiated by krypton ion laser light (647 and 676 nm; 90 J cm-2) 15 min and 24 h after chlorin e6 injection at doses of 5 and 10 mg kg-1. The relationship between some morphological peculiarities of these tumour strains, photosensitizer accumulation in tumours and their response to the photodynamic treatment is discussed.
可移植大鼠肿瘤（M-1肉瘤、45肉瘤、PC-1肺泡肝癌和普利斯氏淋巴肉瘤）用于研究二氢卟吩e6在肿瘤中的蓄积及其光动力效应。在以5和10 mg kg-1的剂量注射二氢卟吩e6后15分钟和24小时，用氪离子激光（647和676 nm；90 J cm-2）照射肿瘤。讨论了这些肿瘤株的一些形态学特征、光敏剂在肿瘤中的蓄积及其对光动力治疗反应之间的关系。
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