KNIGHT A, WILKINSON R D
Can Med Assoc J. 1963 Jun 15;88(24):1193-5.
Biological false positive serologic reactors were studied during a long-term follow-up of asymptomatic patients with chronic false positive serology for syphilitic reagin. This was done with a view to facilitating the early diagnosis of systemic disease, particularly collagen disorders, which are frequently associated with this finding in women. One hundred and thirteen cases were studied. Thirty-eight were "acute", i.e. positive for less than six months, 58 were "chronic", i.e. positive for more than six months, and the remainder still positive but followed for less than six months. Of 39 female chronic reactors, 10 were diagnosed as having collagen disease, and in six the BFP reaction preceded clinical diagnosis of the disease. Five had no apparent disease. In 19 male chronic reactors, there was no evidence of collagen disorders and five were free of any recognizable pathology. The remainder in both sexes were found to have a wide variety of systemic illnesses.
对梅毒反应素慢性假阳性的无症状患者进行了长期随访，研究了生物学假阳性血清学反应者。这样做是为了便于早期诊断全身性疾病，尤其是胶原病，在女性中这种疾病常伴有这一检查结果。共研究了113例病例。38例为“急性”，即阳性持续时间少于6个月；58例为“慢性”，即阳性持续时间超过6个月；其余病例仍为阳性，但随访时间少于6个月。在39例女性慢性反应者中，10例被诊断患有胶原病，其中6例生物学假阳性反应先于疾病的临床诊断。5例无明显疾病。在19例男性慢性反应者中，没有胶原病的证据，5例没有任何可识别的病理情况。男女其余病例被发现患有各种各样的全身性疾病。
