Ho P W, Pein F D, Pruett K A
West J Med. 1980 Jun;132(6):485-7.
A retrospective review of 8,100 serologic tests for syphilis ordered during a 42-month period yielded positive rapid plasma reagin test results in 127 patients (1.6 percent) and a positive fluorescent treponemal antibody absorption reaction in 91 patients (1.1 percent). Of the 36 cases of biologic false-positive reactions, most were in prenatal patients. Forty-six cases of syphilis were previously undiagnosed but antibiotic therapy was given in only 26 of the patients. Some 24 percent of syphilitic patients were not treated because the positive serologic findings were overlooked. Cerebrospinal fluid determinations were analyzed and cost-effectiveness of finding a single case of previously undiagnosed syphilis was calculated. We found that routine serologic tests and cerebrospinal fluid studies for syphilis in asymptomatic patients had low rates of positivity in our community hospital and outpatient practice.
对42个月期间进行的8100次梅毒血清学检测进行回顾性分析，结果显示快速血浆反应素试验结果阳性的患者有127例（1.6%），荧光密螺旋体抗体吸收反应阳性的患者有91例（1.1%）。在36例生物学假阳性反应病例中，大多数为产前患者。46例梅毒病例此前未被诊断出来，但只有26例患者接受了抗生素治疗。约24%的梅毒患者未接受治疗，原因是血清学阳性结果被忽视。对脑脊液检测结果进行了分析，并计算了发现一例此前未诊断出的梅毒病例的成本效益。我们发现，在我们社区医院和门诊实践中，无症状患者进行梅毒常规血清学检测和脑脊液检查的阳性率较低。
