萘普生的氧化脱羧作用。
Oxidative decarboxylation of naproxen.
作者信息
Boscá F, Martínez-Máñez R, Miranda M A, Primo J, Soto J, Vañó L
机构信息
Departamento de Química, Universidad Politécnica de Valencia, Spain.
出版信息
J Pharm Sci. 1992 May;81(5):479-82. doi: 10.1002/jps.2600810519.
PMID:1403685
Abstract
The decarboxylation of naproxen (1H) and its salt (1-) was achieved by means of chemical [Ce(IV) or S2O8(2-)] and electrochemical oxidation. The product patterns were compatible with mechanisms involving single-electron transfer from the pi-system or the carboxylate moiety. The results are discussed in connection with the involvement of electron-transfer processes in the reported phototoxicity of naproxen.
摘要
通过化学氧化（铈（IV）或过二硫酸盐（2-））和电化学氧化实现了萘普生（1H）及其盐（1-）的脱羧反应。产物模式与涉及从π-体系或羧酸盐部分进行单电子转移的机制相符。结合电子转移过程在萘普生报道的光毒性中的作用对结果进行了讨论。
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