Salim A S
University Department of Surgery, Royal Infirmary, Glasgow, U.K.
J Pharm Sci. 1992 Jul;81(7):698-700. doi: 10.1002/jps.2600810722.
Reserpine (intraperitoneal, 5 mg/kg every day for 5 days) produced chronic ulceration of the rat stomach 2 weeks postdose. Gavage with 1% DL-cysteine or DL-methionine-S-methylsulfonium chloride at 1 mL/day for 2 weeks and 5 days protected against ulceration in 30% of the rats, and this protection extended to 80% of cases with 2% solutions. Similar gavage with 5% solutions protected all rats against ulceration without significantly influencing the basal H+ output [13.1 +/- 0.3 and 14.2 +/- 0.2 mumol for DL-cysteine and DL-methionine-S-methylsulfonium chloride, respectively, versus 15.1 +/- 0.4 mumol (mean +/- standard error of the mean; n = 10)]; that is, cytoprotection was achieved.
利血平（腹腔注射，每天5毫克/千克，共5天）给药2周后可导致大鼠胃慢性溃疡。每天以1毫升的剂量灌胃1%的DL-半胱氨酸或DL-甲硫氨酸-S-甲基氯化物，持续2周零5天，可使30%的大鼠免受溃疡侵害，而使用2%的溶液时，这种保护作用可扩展至80%的病例。类似地，用5%的溶液灌胃可使所有大鼠免受溃疡侵害，且对基础氢离子分泌无显著影响[DL-半胱氨酸和DL-甲硫氨酸-S-甲基氯化物分别为13.1±0.3和14.2±0.2微摩尔，而对照组为15.1±0.4微摩尔（平均值±平均标准误差；n = 10）]；也就是说，实现了细胞保护作用。
