Puhakka H, Rantanen T, Virolainen E
J Int Med Res. 1977;5(1):37-41. doi: 10.1177/030006057700500106.
In a double-blind study, diphenylpyraline (Lergobine) was given to 63 patients whose main symptoms were stuffiness of the nose, increased secretion of mucus, snuffling, sneezing and redness of the eyes. Fifty-seven patients were given placebo for identical symptoms. Diphenylpyraline was found to have a better effect on all the symptoms than placebo. The difference was statistically significant in respect of the discharge of mucus and redness of the eyes, and when the total symptoms were considered as a whole. In atopic patients the better effect of diphenylpyraline was highly significant.
在一项双盲研究中，给63名主要症状为鼻塞、黏液分泌增多、抽鼻涕、打喷嚏和眼睛发红的患者服用了二苯拉林（Lergobine）。给57名有相同症状的患者服用了安慰剂。结果发现，二苯拉林对所有症状的疗效均优于安慰剂。在黏液分泌和眼睛发红方面，以及将所有症状作为一个整体考虑时，差异具有统计学意义。在特应性患者中，二苯拉林的较好疗效非常显著。
