BRONK J R
Science. 1963 Aug 30;141(3583):816-8. doi: 10.1126/science.141.3583.816.
Triiodothyronine administered to thyroidectomized rats preferentially increased the total capacity of the electron transport phosphorylation system when isolated mitochondria from the liver were tested with different substrates, but it caused little increase in the activity of the slowest dehydrogenases and no uncoupling. The increased activity appeared to be partly due to direct activation of some component of the electron transport system, although triiodothyronine injection also stimulated the incorporation of amino acids by isolated mitochondria.
给甲状腺切除的大鼠注射三碘甲状腺原氨酸后，在用不同底物测试肝脏分离线粒体时，优先增加了电子传递磷酸化系统的总容量，但对最慢的脱氢酶活性几乎没有增加，也没有解偶联现象。活性增加似乎部分是由于电子传递系统某些成分的直接激活，尽管注射三碘甲状腺原氨酸也刺激了分离线粒体对氨基酸的掺入。
