Ljubicić N, Bilić A
Department of Gastroenterology and Hepatology, University of Zagreb, Republic of Croatia.
J Ultrasound Med. 1992 Oct;11(10):517-20. doi: 10.7863/jum.1992.11.10.517.
The effect of acute (80 mg orally) and prolonged (240 mg orally daily for 2 weeks) verapamil administration on portal blood flow was studied in 12 patients with histologically proved alcoholic liver cirrhosis. Portal hemodynamics were examined by the ultrasonic duplex Doppler system. Thirty minutes after acute verapamil administration, the following parameters remained unchanged: (1) cross-sectional area of the portal vein, from 1.52 +/- 0.41 to 1.51 +/- 0.43 cm2; (2) portal blood velocity, from 13.2 +/- 1.6 to 13.4 +/- 1.6 cm/s; (3) estimated volume of portal blood flow, from 931 +/- 96 to 954 +/- 103 mL/min; and (4) congestion index of the portal vein, from 15.1 +/- 8.3 to 15.6 +/- 8.8 cm, respectively (P = > 0.05). In addition, no significant changes in portal blood hemodynamics were noted after prolonged verapamil administration (P > 0.05). These results demonstrated that verapamil did not alter portal blood flow in patients with alcoholic liver cirrhosis.
在12例经组织学证实为酒精性肝硬化的患者中，研究了急性（口服80毫克）和长期（每日口服240毫克，持续2周）维拉帕米给药对门静脉血流的影响。采用超声双功多普勒系统检查门静脉血流动力学。急性给予维拉帕米30分钟后，以下参数保持不变：（1）门静脉横截面积，从1.52±0.41平方厘米变为1.51±0.43平方厘米；（2）门静脉血流速度，从13.2±1.6厘米/秒变为13.4±1.6厘米/秒；（3）估计门静脉血流量，从931±96毫升/分钟变为954±103毫升/分钟；（4）门静脉充血指数，分别从15.1±8.3厘米变为15.6±8.8厘米（P>0.05）。此外，长期给予维拉帕米后门静脉血流动力学无显著变化（P>0.05）。这些结果表明，维拉帕米不会改变酒精性肝硬化患者的门静脉血流。
