Takeda M, Tachibana H, Sugita M, Hirayama H, Miyauchi M, Matsuoka A
5th Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya.
Rinsho Byori. 1992 Aug;40(8):896-900.
The event-related potential (ERP) was recorded for 24 patients with diabetes mellitus (age 67.5 +/- 8.5 years, mean +/- SD) and 28 healthy controls (age 61.0 +/- 10.6 years) to elucidate the involvement of the central nervous system (CNS) in diabetes mellitus. ERP was recorded during auditory discriminative tasks. The latencies of N100, P200, N200 and P300 from the Pz region were measured. Patients with diabetes mellitus showed significant prolongation of N200 and P300 latencies compared with the normal subjects, while no significant differences in N100 and P200 latencies were found between the two groups. In six of 24 patients, the P300 latency delayed beyond the 2SD of the appropriate age-related value estimated from the normal regression line. The delay of the P300 latency was not related to either the duration of illness, therapeutic methods, or metabolic control. From the present results, it would appear that higher brain function is impaired even in diabetic patients not manifesting overt CNS signs and symptoms.
对24例糖尿病患者（年龄67.5±8.5岁，均值±标准差）和28名健康对照者（年龄61.0±10.6岁）进行事件相关电位（ERP）记录，以阐明中枢神经系统（CNS）在糖尿病中的受累情况。ERP在听觉辨别任务期间记录。测量了Pz区域N100、P200、N200和P300的潜伏期。与正常受试者相比，糖尿病患者的N200和P300潜伏期显著延长，而两组之间N100和P200潜伏期未发现显著差异。在24例患者中的6例中，P300潜伏期延迟超过了根据正常回归线估计的适当年龄相关值的2个标准差。P300潜伏期的延迟与病程、治疗方法或代谢控制均无关。从目前的结果来看，即使在没有明显CNS体征和症状的糖尿病患者中，高级脑功能似乎也受到了损害。
