Ohmori S, Harada K, Tajima C, Miura H
Department of Hygiene, Kumamoto University School of Medicine.
Sangyo Igaku. 1992 Sep;34(5):457-63.
An experimental study of sex hormone on FEP level in rats was conducted to clarify sex difference of FEP level. A total of 42 male Donryu rats were divided into 7 groups; group I (control 1; olive oil injection without castration), group II (control 2; olive oil alone), group III (EL; estradiol in olive oil, 50 micrograms/kg.BW), group IV (EH; estradiol in olive oil, 250 micrograms/kg.BW), group II' (Pb; Pb 5 mg/kg.BW), group III' (PbEL; Pb 5 mg/kg.BW + estradiol in olive oil, 50 micrograms/kg.BW) and group IV' (PbEH; Pb 5 mg/kg.BW+estradiol in olive oil, 250 micrograms/kg.BW). Excluding group I, all rats of the 6 groups were castrated. After one week from castration, estradiol was subcutaneously injected 4 times a week, and lead was intraperitoneally injected once a week for 6 wk. Estradiol suppressed growth, Ht, Hb value and liver function, but did not show any evident effect on FEP, ALA-U and CP-U. Erythrocyte ALA-D activity in group IV' (Pb+estradiol at high dose) showed a level higher than that in group II' (Pb-treatment alone).
进行了一项关于性激素对大鼠FEP水平影响的实验研究，以阐明FEP水平的性别差异。将42只雄性唐律大鼠分为7组；第一组（对照1；注射橄榄油但未去势），第二组（对照2；仅注射橄榄油），第三组（EL；橄榄油中含雌二醇，50微克/千克体重），第四组（EH；橄榄油中含雌二醇，250微克/千克体重），第二组'（Pb；5毫克/千克体重的铅），第三组'（PbEL；5毫克/千克体重的铅+橄榄油中含雌二醇，50微克/千克体重）和第四组'（PbEH；5毫克/千克体重的铅+橄榄油中含雌二醇，250微克/千克体重）。除第一组外，其余6组大鼠均进行了去势。去势一周后，每周皮下注射雌二醇4次，每周腹腔注射铅1次，共6周。雌二醇抑制生长、Ht、Hb值和肝功能，但对FEP、ALA-U和CP-U未显示任何明显影响。第四组'（高剂量铅+雌二醇）的红细胞ALA-D活性高于第二组'（仅铅处理）。
