Furuichi Y, Takakura S, Satoh H, Mori J, Kohsaka M
Department of Pharmacology, Fujisawa Pharmaceutical Co., Ltd., Osaka, Japan.
Jpn J Pharmacol. 1992 Apr;58(4):457-60. doi: 10.1254/jjp.58.457.
The effect of nilvadipine, a dihydropyridine type calcium channel blocker, on local cerebral blood flow (lCBF) was investigated using the autoradiographic iodo[14C]antipyrine technique in rats. In control rats, lCBF in cortical areas and in the superior colliculus and inferior colliculus was higher than that in the hippocampus, septal nucleus, globus pallidus and substantia nigra. Nilvadipine (32 micrograms/kg, i.v.) increased lCBF in all structures (significantly in 11 of 21 structures) in spite of a 33% reduction in mean arterial blood pressure. These results confirm that nilvadipine has the ability to increase cerebral blood flow.
使用放射性自显影碘[¹⁴C]安替比林技术在大鼠中研究了二氢吡啶类钙通道阻滞剂尼伐地平对局部脑血流量（lCBF）的影响。在对照大鼠中，皮质区域、上丘和下丘中的lCBF高于海马、隔核、苍白球和黑质中的lCBF。尽管平均动脉血压降低了33%，尼伐地平（32微克/千克，静脉注射）仍使所有结构中的lCBF增加（21个结构中的11个显著增加）。这些结果证实尼伐地平具有增加脑血流量的能力。
