Sone H, Okuda Y, Mizutani M, Kawakami Y, Bannai C, Yamashita K
Department of Internal Medicine, University of Tsukuba, Japan.
Postgrad Med J. 1995 Oct;71(840):613-6. doi: 10.1136/pgmj.71.840.613.
The effects of nilvadipine on the peripheral circulation in the lower extremities using a duplex system of two-dimensional colour and pulse Doppler ultrasonography were studied in 32 patients with type 2 diabetes mellitus and mild essential hypertension. The patients (19 men and 13 women) were randomly divided into treatment and control groups. The anatomical cross-sectional area and blood flow index of the dorsal pedis artery were determined by colour and pulse Doppler ultrasonography before and 60 min after administration of 4 mg nilvadipine or placebo. Pulse rate and blood pressure were measured simultaneously. There were no significant changes in pulse rate or blood pressure after administration of either drug. Both cross-sectional areas (from 4.3 +/- 0.4 to 5.2 +/- 0.5 mm2, p < 0.05) and blood flow index (from 40.3 +/- 4.3 to 58.8 +/- 9.0, p < 0.05) were significantly increased in the treatment group, whereas there were no significant changes in either measurement in the control group. The findings showed that a single administration of nilvadipine increases blood flow in the dorsal pedis arteries of diabetic patients.
采用二维彩色和脉冲多普勒超声双功系统，研究了尼伐地平对32例2型糖尿病合并轻度原发性高血压患者下肢外周循环的影响。患者（19例男性和13例女性）被随机分为治疗组和对照组。在服用4mg尼伐地平或安慰剂前及给药60分钟后，通过彩色和脉冲多普勒超声测定足背动脉的解剖横截面积和血流指数。同时测量脉搏率和血压。两种药物给药后脉搏率或血压均无显著变化。治疗组的横截面积（从4.3±0.4增加到5.2±0.5mm²，p<0.05）和血流指数（从40.3±4.3增加到58.8±9.0，p<0.05）均显著增加，而对照组的这两项测量值均无显著变化。研究结果表明，单次服用尼伐地平可增加糖尿病患者足背动脉的血流量。
