Cotrim E, Zaterka S, Walsh J
Gastroenterology. 1977 Apr;72(4 Pt 1):676-9.
In 16 healthy subjects, gastric distention was produced by infusion of 5% mannitol solution, pH 5.5. Constant intragastric pressure was maintained by use of a barostat. Over successive 1-hr periods the head of pressure was raised in 5-cm increments from an arbitrary zero point to 15 cm. Gastric acid secretion was measured by constant intragastric titration. Blood samples were obtained throughout the study for measurement of serum gastrin concentrations. When intragastric pressure was raised from zero to 5 cm H2O, gastric acid secretion increased significantly (24% of peak acid response to pentagastrin). Acid responses at 10 and 15 cm pressure were lower. Serum gastrin concentrations increased slightly at 15 cm pressure but not at 5 or 10 cm. There was no correlation between increments in serum gastrin and acid secretory rates. We conclude that gastric distention at low pressures stimulated acid secretion by a mechanism and did not involve increases in circulating gastrin concentrations. Slight increases in serum gastrin observed at the highest distending pressure were not associated with further increases in acid secretion.
在16名健康受试者中，通过输注pH值为5.5的5%甘露醇溶液引起胃扩张。使用压力调节器维持恒定的胃内压力。在连续的1小时时间段内，压力头从任意零点以5厘米的增量升高至15厘米。通过恒定的胃内滴定法测量胃酸分泌。在整个研究过程中采集血样以测量血清胃泌素浓度。当胃内压力从零升高到5厘米水柱时，胃酸分泌显著增加（达到对五肽胃泌素的最大酸反应的24%）。在10厘米和15厘米压力下的酸反应较低。血清胃泌素浓度在15厘米压力时略有增加，但在5厘米或10厘米时没有增加。血清胃泌素的增加与酸分泌率之间没有相关性。我们得出结论，低压下的胃扩张通过一种机制刺激酸分泌，且不涉及循环胃泌素浓度的增加。在最高扩张压力下观察到的血清胃泌素的轻微增加与酸分泌的进一步增加无关。
