Konturek S J, Biernat J, Oleksy J, Rehfeld J F, Stadil F
J Clin Invest. 1974 Sep;54(3):593-7. doi: 10.1172/JCI107796.
The action of intravenous atropine on meal-and pentagastrin-induced gastric acid secretion was studied in six duodenal ulcer patients.A test meal of 10% peptone solution adjusted to pH 5.0 was maintained in the stomach at at distention presure of 15 cm H(2)O, and a modification of the intragastric titration method of Fordtran and Walsh was used to measure gastric acid output by monitoring the rate at which a solution of 0.5 M sodium bicarbonate had to be added to keep the pH of the gastric content constant at the initial (pH 5.0) value. Serum gastrin concentrations were measured simultaneously by radioimmunoassy. The dose of 25 mug/kg-h atropine inhibited meal-induced acid secretion by about 70% and that evoked by pentagastrin by about 30%. The serum gastrin response to the test meal was not significantly altered by atropine. We conclude that atropine is a very strong inhibitor of meal-induced gastric acid secretion and does not significantly change serum gastrin response to feeding in duodenal ulcer patients when postprandial gastric acidity (pH 5.0) and intragastric pressure (15 cm H(2)O) are kept constant.
在6例十二指肠溃疡患者中研究了静脉注射阿托品对进餐及五肽胃泌素诱导的胃酸分泌的作用。将pH值调至5.0的10%蛋白胨溶液作为试餐，以15 cm H₂O的扩张压力维持在胃内，并采用Fordtran和Walsh胃内滴定法的改良方法，通过监测添加0.5 M碳酸氢钠溶液以保持胃内容物pH值恒定在初始值（pH 5.0）的速率来测量胃酸分泌量。同时通过放射免疫分析测定血清胃泌素浓度。25 μg/kg-h剂量的阿托品可使进餐诱导的胃酸分泌抑制约70%，使五肽胃泌素诱导的胃酸分泌抑制约30%。阿托品对试餐引起的血清胃泌素反应无明显改变。我们得出结论，当餐后胃酸度（pH 5.0）和胃内压力（15 cm H₂O）保持恒定时，阿托品是进餐诱导的胃酸分泌的强效抑制剂，且不会显著改变十二指肠溃疡患者进食后血清胃泌素反应。
