SBARRA A J, SHIRLEY W
J Bacteriol. 1963 Aug;86(2):259-65. doi: 10.1128/jb.86.2.259-265.1963.
Sbarra, Anthony J. (St. Margaret's Hospital, Boston, Mass.) and William Shirley. Phagocytosis inhibition and reversal. I. Effect of glycolytic intermediates and nucleotides on particle uptake. J. Bacteriol. 86:259-265. 1963.-By microscopically monitoring phagocytosis and following the biochemical changes associated with this process, the inhibition of phagocytosis by fluoride or iodoacetate was shown to be partially reversed by pyruvate. This reversal occurred with both inhibitors, either aerobically or anaerobically. Nicotinamide adenine dinucleotide (NAD) apparently increased the degree of pyruvate reversal when fluoride, but not iodoacetate, was the inhibitory agent. Lactate under some conditions was also shown to reverse the inhibition. It is suggested that pyruvate and NAD are key compounds for the phagocytic process.
斯巴拉，安东尼·J.（马萨诸塞州波士顿圣玛格丽特医院）和威廉·雪莉。吞噬作用的抑制与逆转。I.糖酵解中间产物和核苷酸对颗粒摄取的影响。《细菌学杂志》86:259 - 265。1963年。——通过显微镜监测吞噬作用并跟踪与此过程相关的生化变化，发现氟化物或碘乙酸对吞噬作用的抑制可被丙酮酸部分逆转。两种抑制剂在有氧或无氧条件下均出现这种逆转。当抑制剂为氟化物而非碘乙酸时，烟酰胺腺嘌呤二核苷酸（NAD）明显增加了丙酮酸逆转的程度。在某些条件下，乳酸也被证明可逆转这种抑制。有人提出丙酮酸和NAD是吞噬过程的关键化合物。
