Freeman S B, Markwell J K
Department of Otolaryngology/Head and Neck Surgery, Naval Hospital, Portsmouth, Va.
Laryngoscope. 1992 Nov;102(11):1242-6. doi: 10.1288/00005537-199211000-00007.
Tonsillectomy results in severe throat pain, ear pain, and trismus until the exposed and inflamed muscle becomes covered with regenerated mucosa. Sucralfate binds with the fibrinous exudate of duodenal ulcers, forming a protective barrier that promotes healing. If a similar buffer could be created in the tonsillar bed, morbidity may be diminished. A double-blind, randomized study was completed in 34 adult patients to determine whether sucralfate, given four times daily for 10 days as a swish and swallow, would significantly reduce postoperative pain and promote healing and recovery. Sucralfate significantly lowered postoperative throat pain, otalgia, and trismus. Sucralfate is a safe and well-tolerated topical agent that offers significant pain reduction and may promote healing in tonsillectomy patients.
扁桃体切除术后会出现严重的咽痛、耳痛和牙关紧闭，直到暴露且发炎的肌肉被再生的黏膜覆盖。硫糖铝与十二指肠溃疡的纤维蛋白渗出物结合，形成促进愈合的保护屏障。如果能在扁桃体床形成类似的缓冲层，发病率可能会降低。一项针对34名成年患者的双盲随机研究完成，以确定硫糖铝作为含漱后咽下的药物，每日四次、连续使用10天，是否能显著减轻术后疼痛并促进愈合和恢复。硫糖铝显著降低了术后咽痛、耳痛和牙关紧闭的程度。硫糖铝是一种安全且耐受性良好的局部用药，可显著减轻疼痛，并可能促进扁桃体切除术后患者的愈合。
