Stahl S M
Arch Gen Psychiatry. 1977 May;34(5):509-16. doi: 10.1001/archpsyc.1977.01770170019001.
Comparison of the properties of blood platelets and serotonergic synaptosomes suggests that the human platelet can serve as an appropriate model for the transport, metabolism, and release of serotonin (5-HT) by CNS serotonergic neurons. The study of blood 5-HT levels and platelet 5-HT pharmacodynamics in patients with a variety of psychiatric and neurologic disorders has generated interesting leads into possible abnormalities of CNS 5-HT neurons in these patients. This article reviews the experimental evidence, which uses the human platelet model to investigate neurotransmitter-related abnormalities in Down syndrome, mental retardation, infantile autism, hyperactivity syndromes (minimal brain dysfunction), schizophrenia, affective disorders, Duchenne muscular dystrophy, Parkinson disease, Huntington chorea, and migraine headaches.
血小板与血清素能突触体特性的比较表明，人类血小板可作为中枢神经系统血清素能神经元转运、代谢和释放血清素（5-羟色胺，5-HT）的合适模型。对患有各种精神和神经疾病患者的血液5-HT水平及血小板5-HT药效学的研究，为这些患者中枢神经系统5-HT神经元可能存在的异常情况带来了有趣的线索。本文综述了相关实验证据，这些证据利用人类血小板模型来研究唐氏综合征、智力迟钝、婴儿自闭症、多动综合征（轻微脑功能障碍）、精神分裂症、情感障碍、杜兴氏肌营养不良症、帕金森病、亨廷顿舞蹈症和偏头痛患者中与神经递质相关的异常情况。
