Barzen G, Martini I, Schulz W, Löhde E, Böse-Landgraf J, Richter W, Langer M, Felix R
Strahlenklinik und Poliklinik, Klinikum Rudolf Virchow, Freien Universität, Berlin.
Med Klin (Munich). 1992 Aug 15;87(8):395-402.
In Germany, radioimmunoscintigraphy (RIS) (scintigraphic, specific imaging of benign and malignant diseases by radioactively labelled monoclonal antibodies) has been employed since 1985 in clinical trials involving patients with colorectal cancer. After proving successful for identifying primary tumors, RIS is now increasingly being used for the early diagnosis of recurrent and metastatic lesions. In this prospective study involving 75 patients with colorectal tumors confirmed by endoscopy and biopsy, it was shown that RIS using the SPECT technique with 99m-Tc-labelled monoclonal CEA antibodies has a sensitivity of 78% in the detection of local recurrent disease in cases in which diagnostic work-up has been inconclusive.
在德国，自1985年起，放射免疫闪烁造影术（RIS）（通过放射性标记单克隆抗体对良性和恶性疾病进行闪烁造影特异性成像）就已被用于涉及结直肠癌患者的临床试验。在证明对识别原发性肿瘤有效后，RIS现在越来越多地用于复发性和转移性病变的早期诊断。在这项涉及75例经内镜检查和活检确诊为结直肠肿瘤患者的前瞻性研究中，结果表明，使用99m-Tc标记的单克隆癌胚抗原（CEA）抗体的SPECT技术的RIS在诊断检查结果不明确的病例中检测局部复发性疾病的敏感性为78%。
