Barzen G, Zwicker C, Neumann K, Löhde E, Raakow R, Böse-Landgraf W, Richter W, Hierholzer J, Langer M, Felix R
Strahlenklinik und Poliklinik, Klinikum Rudolf Virchow, Freie Universität Berlin.
Rofo. 1992 Jan;156(1):3-10. doi: 10.1055/s-2008-1032827.
Radioimmunoscintigraphy (= RIS, scintigraphic "specific" imaging of benign and malignant diseases by means of radioactively marked monoclonal antibodies) has been performed in Germany in clinical studies since 1985 in patients suffering from colorectal cancer. After having been successfully proven in primary studies, RIS is now being used in the early diagnosis of recurrences and metastases. In the prospective study presented here the clinical usefulness of RIS was assessed in comparison against well-tried diagnostic methods including computed tomography in patients suffering from colorectal cancer. It was shown that RIS in SPECT technique (= single photon emission computed tomography) with 99mTc-labelled monoclonal CEA antibodies can visualise local recurrences if diagnostic findings are doubtful, with a sensitivity of 78% versus 50% for CT findings.
自1985年以来，德国已对患有结直肠癌的患者开展了放射免疫闪烁显像（=RIS，即通过放射性标记的单克隆抗体对良性和恶性疾病进行闪烁显像“特异性”成像）的临床研究。在初步研究中得到成功验证后，RIS目前正用于复发和转移的早期诊断。在此呈现的前瞻性研究中，针对患有结直肠癌的患者，将RIS与包括计算机断层扫描在内的成熟诊断方法进行比较，评估了RIS的临床实用性。结果表明，采用99mTc标记的单克隆癌胚抗原（CEA）抗体的SPECT技术（=单光子发射计算机断层扫描）进行RIS检查时，如果诊断结果存疑，其可显示局部复发，敏感性为78%，而CT检查结果的敏感性为50%。
