三乙胆碱对豚鼠回肠蠕动反射的作用
THE ACTION OF TRIETHYLCHOLINE ON THE PERISTALTIC REFLEX OF THE GUINEA-PIG ILEUM.
作者信息
BOULLIN D J
出版信息
Br J Pharmacol Chemother. 1963 Aug;21(1):208-14. doi: 10.1111/j.1476-5381.1963.tb01517.x.
The action of triethylcholine on the peristaltic reflex of the guinea-pig isolated ileum has been studied. When perfused through the lumen in low concentrations triethylcholine first stimulated and then inhibited peristalsis. High concentrations gradually inhibited or abolished the reflex without prior stimulation. These inhibitory effects were reversed by choline, in the continued presence of triethylcholine. Similar responses followed application of triethylcholine to the serosal surface of the gut, except that high concentrations produced an immediate abolition of peristalsis which was not restored by choline. It is suggested that the effects of intraluminal triethylcholine are due either to enhancement of acetylcholine release or to reduction of acetylcholine synthesis, or to a combination of these factors, and that the results are evidence that acetylcholine is a humoral transmitter involved in the initiation of peristalsis.
研究了三乙胆碱对豚鼠离体回肠蠕动反射的作用。当以低浓度经肠腔灌注时，三乙胆碱首先刺激然后抑制蠕动。高浓度时则逐渐抑制或消除反射，且无先前的刺激作用。在三乙胆碱持续存在的情况下，胆碱可逆转这些抑制作用。将三乙胆碱应用于肠的浆膜表面也会出现类似反应，只是高浓度时会立即消除蠕动，且胆碱不能使其恢复。有人认为，肠腔内三乙胆碱的作用要么是由于乙酰胆碱释放增强，要么是由于乙酰胆碱合成减少，或者是这些因素的综合作用，并且这些结果证明乙酰胆碱是参与蠕动起始的一种体液递质。
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